This meta-analysis of 27 published studies found that floatation is helpful for managing stress, in addition to or instead of other stress management tools. Flotation is unique is that it has “relaxing, mood-, and performance-enhancing effects that seem to be more profound than those of other relaxation techniques.

Van Dierendonck, Dirk. “Flotation restricted environmental stimulation therapy (REST) as a stress-management tool: A meta-analysis.” Psychology and Health, Jan Te Nijenhuis, 20(3), 2005, 405–412.